Cialis (INTRODUCTION)
Tadalafil (Cialis®) is an oral medication indicated for the treatment of
erectile dysfunction (ED). This chapter reviews the current state of knowledge
of the pharmacodynamics, pharmacokinetics, effectiveness, and
safety of tadalafil. Data are derived from clinical trials involving more
than 5700 men with mild to severe ED of various causes regardless of the
presence of major comorbidities, such as diabetes and hypertension.
In clinical studies, tadalafil has been shown to have a unique pharmacokinetic
profile, which includes a long duration of action, up to 36 h.
This has the potential to provide couples with increased flexibility by
minimizing the need to schedule sexual activity around time of day.
Additionally, one study has shown that the rate and extent of tadalafil
absorption is not affected by the presence of high-fat food, which also translates into increased flexibility for couples by minimizing the need to schedule sexual activity around mealtimes.
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